Heya,
If it helps, I play without any other gameplay changing mods, just Factorio+
Enemies are not a huge issue early on, and water slows them down as well so having some early turrets on the edges of the water helps to find stragglers until you get landfill.
I'm not quite at the stage to support very specific other mods, so you will have to hang tight. Be sure to look at the enemy health settings if it's too difficult.
Cheers!