I'm running the latest versions of krastorio 2 and Factorio (1.1.5) at the time of writing.
I'm only using a few qol mods such as time tools, to-do list, base planner and even distribution etc..
Krastorio 2 was added before generating a new map to test.
The game freezes every few seconds (5-10) making it an unpleasant experience (my hardware is capable of running really heavy softwares).
I'm expecting the topic to be looked into as it seems to be only caused by this specific mod (I turned off every single other mod at some point and the case still occurred).
No crashes hopefully yet.
Edit: The freezing/lag starts with the start of the game, it is still present before building anything at all or even mining the first resources.
Edit2: I didn't modify any the of mod settings, running it on the default settings.