Hi, I'd like to announce that I've adapted my Google spreadsheet (https://forums.factorio.com/viewtopic.php?f=134&t=27467) for Krastorio 2. It's available here:

https://docs.google.com/spreadsheets/d/1AHuzMI6yw1fw7eDu7LPfq9qBLcTAhxW199o_znm6lcc/edit

See the forum post above for what it can do. The essential features for the Krastorio 2 variant are the same as described there, but a lot has changed under the hood to support the more complex production chains, in particular the much more numerous alternative recipes for many items and the production loops that easily occur in Krastorio 2 (anyone who has played it for a little bit has probably run into the enriched iron -> iron plate -> sulfuric acid -> enriched iron loop, for instance).

It should be simple enough to use to answer simple questions like "how many greenhouses do I need to produce 500 electronic circuits per minute". It can also do advanced calculations balancing different production methods for various production stages, factoring in recycling of water, accounting for byproduct ores coming from water filtration and uranium processing, etc, although that requires a bit more effort and reading of docs.

It handles all recipes, items and production categories in Krastorio 2. The one limitation is that it won't show inserter counts for advanced and superior belts and inserters. Getting the numbers for that requires lots of in-game measurements which I haven't had time to do.

I hope it's useful for some out there!