The first virus grenade (slime-virus) removes all slime from the map (revealed?). It freezes the game few minutes, after it I save the game and it crashes. Factorio 1.0 with map 1.0, Mods: Krastorio 1.0.4 (new game), Alien biomes 0.5.8, Helmod 0.11.1. No console commands are used. Reproduced few times, maybe slime removing was in progress and prevented saving. In the log last action was:
4667.456 Info AppManager.cpp:298: Saving to _autosave3 (blocking).