I wonder if it would be desirable to put biochamber and ag tower behind trigger unlocks instead of research unlocks. 2.1 allows up to 100000x science multiplier, which would be practically impossible to do since you would have to gather enough bacteria by hand to do 2 million science for each one. I've been doing a 100x run, and unlocking towers and chambers was annoying enough in that one I would hate to try anything higher.