That would be cool for an option but to be honest I personally would not play with those limits, even if I try to make my blueprints work on hexagons, sometimes for aesthetics or function I have to "invade" the gaps.
Also I think if that becomes an option allowing to build trains and stations is a good idea, focusing the gaps as "transport" areas rather than outright restrict (tho I am having issues setting up trains along the small default sized gaps)