First off, I would suggest backing up your save, just in case. I can't guarantee it works with any mod, though I tried my best to avoid general causes for the game to break due to compatibility issues.
It depends if you have Space Age or not.
The current version (0.35.1) in vanilla has a decently powerful faction, would cause you some trouble, especially if they start eating the materials on your belts and growing in numbers because of that. Also, capturing your chests will make them explode based on how full the chest was. the more you explore new chunks, the more bases will spawn, and the faster they will grow and advance in tech. They will become much more powerful the more you let them research, as they have infinite techs, just like the players.
With Space Age, the stage 4 bases get an upgrade with Space Age weapons, there's a new type of "space ship" (custom scripted asteroid) that spawns an attack on your space platforms (comes in all 4 standard sizes). You also get a planet that has stage 5+ bases, that if you let grow, will become a serious threat (expect waves of 1000+ walkers from different directions at once). I also plan to add a boss fight soon. Going to the planet itself unlocks some, hopefully, fun (I had a lot of fun with them myself) techs. Should be perfectly compatible with old saves.