Update:
Still happens with latest version (all mods say up to date), and a small test modlist.
Orbital Ion Cannon (Space Edition), Kux-CoreLib, Space Age, Quality, Elevated Rails, ERM (post process, libraries, asset pack...) ERM Protoss (asset pack), ERM Zerg (asset pack).
Firing an ion cannon causes the same error as above.
Doesn't seem to matter if it hits a biter nest, or empty space.