I beat it with just under 11h of playtime (but probably less actual time because I did use speedup a bit)
I loved the transition from manual shard duplication -> better and automatic shard duplication -> shard conjuration (when that recipe finally makes more than 10 shard per orb)
I wish the haste orbs would stack. Later I was adding those to all the machines, and it was kinda annoying how much inventory space they were taking.
Here's my (almost) one screen final factory: https://imgur.com/a/d7IJ9y8
The combat options are interesting, but without a radar it was annoying. I ended up disabling enemies when biters started attacking random bits of my factory far away from me.
When I opened the end portal I couldn't walk through it? and it didnt trigger "you win" screen either?
also for me figuring out the 2nd and 3rd science pack was actually easier than the first one lol. The belt timer trick works nicely for the divination, and I kinda just skipped automating the last one. Maybe the adjustable inserters made some parts very easy too. Making inserter insert into the same machine is very strong.