Hello again,
Want to share some things.
I built around 450 combinators while my storage was relatively full (around 150 item types) and yes, game started lag each second and yes it is linked with combinators. When I commented a piece of code that iterates over the storage and creates a signal for each item type, lags disappeared so I can confirm which exact part of code causes UPS drop.
Now bad news, I utilized a Factorio 2.0 new feature when you could create a single logistic signals group and assign a name for it to reuse later and even despite I only update 1 combinator, game itself struggles to update the rest 449 and lag returns. Based on this I can make a conclusion that it is very hard for game to update 450 entities with that big amount of signals.
Then I tried another thing and made combinators keep only 1 signal, it works excellent with no issues to update 450 combinators with only first item in storage, so the key to resolve this problem is to create another type of combinator where you can set a limited amount of signals manually and then mod just will keep that signal values up to date. Say you place that combinator, create "iron plate" signal and it always outputs how many iron plates are in storage. So you could have very limited amount of classic combinators for displaying and entire storage and then have big amount of that new limited combinators to only output those signals that are important in each particular location.
Will that work for you?