It's hard to say given you have long list of mods.
Any combat mod will change the balance of it. It may make the mod feel too easy if the weapons are OP.
An overhaul mod may throw the balance off as well. E.g it may slow down weapon research which indirectly increase difficulty. The enemy evolve faster than you can handle with low level weapons.
Given it's your first time. It's probably ideal stick with mostly default difficulty to start and set "nauvis enemy" to the ones you want to try. Then you can tune the difficulty settings in map setting if you find it too easy / hard with your set of mods. You'll have to explore the balance.
If you feel adventurous, you can enable zerg on vulcanus and protoss on fulgora. I don't recommend on first try tho, especially if you enable them on nauvis.