Units spawn with unique stats. Medium, Big, Behemoth and Giant Biters may appear at the beginning of the game, but with a small probability.
Mods introducing new content into the game.
New ways to deal with enemies, be it attack or defense.
Changes to enemies or entirely new enemies to deal with.
Every time you change a mod in your game and continue to play your enemy evolution update runs which destroys the evolution over time. Get numbers like time factor: 0.00000005, same with pollution and destroy.