Build your base on a platform that warps from planet to planet and escape biters before they overwhelm you.
Large total conversion mods.
Augmented or new ways of transporting materials - belts, inserters, pipes!
New ways to deal with enemies, be it attack or defense.
Changes to enemies or entirely new enemies to deal with.
Map generation and terrain modification.
Changes to power production and distribution.
The Link to Eggceptional's play though is wrong. It points somewhere under 'mods.factorio.com' instead of to 'youtube.com'.
(is: "https://mods.factorio.com/mod/www.youtube.com/watch?v=MPK-nKyrwgk" but should be "https://www.youtube.com/watch?v=MPK-nKyrwgk")
Thank you for noticing that. Its now fixed
