Build your base on a platform that warps from planet to planet and escape biters before they overwhelm you.
Large total conversion mods.
Augmented or new ways of transporting materials - belts, inserters, pipes!
New ways to deal with enemies, be it attack or defense.
Changes to enemies or entirely new enemies to deal with.
Map generation and terrain modification.
Changes to power production and distribution.
The cliff has been brought to the platform. When I was expanding the platform on Garden Planet, the platform covered the nearest cliff and took it away. This is annoying. I haven't pointed out the cliff bomb technology yet