The start was definitely a grind. I did end up raising my wave time to 4 minutes, so mileage may vary. For me, the game really opened up when I did the first Gleba science-based platform upgrade, but once that happened, a bunch of things opened up for me. I did a lot of burner drill mining/smelting to start, with turrets and bullets constantly being handcrafted. I prioritized some damage/speed upgrades. You don't have to wait for the timer to count down to warp, if you see a planet you need come up next, warp, and always be ready to pick up your stuff so you can.
If you've made it to blue, you might have passed the hardest grind because opening up other planets gives you some options. Gleba bacteria harvesting can give you whole inventories of ore, and once I started that, I moved my smelting to on platform. From there, it's small builds so you can make consistent progress on resources, and as you expand the platform or factory, you can grow those builds. I borrowed a nice little sushi belt setup from Venca in Discord to handle red/green/blue science and, as the factory floor size increased, added military/purple/yellow.
Probably my most brutal realization/grind was trying to do some "smart" science setups with circuit-based recipe changes, not realizing that you can only set some of those when you are on the right planet. This made my initial Gleba science grind take awhile because I had to stick around there for that science. Once my platform had enough room and I moved away from those types of builds, things progressed a bit faster.
I'm one platform upgrade, one more factory rework (just increased to final size), and implementing endgame science/win condition research away from completion (this might be another 10-20 hrs BTW :) ). Beyond that, my biggest issue is going to the factory floor and focusing on reworks and not watching the warp time or not realizing I ran out of water/lava/heavy oil and scrambling to wait out the warp timer or the right planet to pop up so I can continue.