Build your factory as a Spidertron from the start! Instead of unlocking better weapons and armor, unlock upgrades to yourself.
Mods introducing new content into the game.
Transportation of the player, be it vehicles or teleporters.
New ways to deal with enemies, be it attack or defense.
Wouldn't it be a nice detail to send mini spidertrons instead of construction drones?
That would be very cool. Unfortunately it as also likely outside the scope of my modding capabilities, but we'll see...