In the original, only some worlds were enemy-free; specifically Uncharted Planets, where the message would show something like "You look around and wonder if this world ever had a name", I assume it used Nauvis' exact map settings. I don't want to play the entire game enemy-free, one of the big draws of Warptorio is the waves and waves of enemies the platform pollution draws. If the old behavior isn't an option, the just having Nauvis be enemy-free and all warp zones having biters is perfectly fine.
Either way, I would like it if disabling biters in the world generation settings didn't break the missions, since that locks you out of accessing most of the game's content.