Maybe only in combination with https://mods.factorio.com/mod/planet-woodoria.
Every few minutes or so, my game froze for a few seconds before it returned to normal UPS. Turns out, this mod's script time (debug F5) rose up to over 200. Literally unplayable.
I believe it's this guy: https://github.com/factorio-plexpt/fruit/blob/90ff9406a9f814a24e4ab9b2e4c1e56f586b9db3/runtime/egg.lua#L38
Since I don't spend time on Woodoria, but have it in my save nonetheless, the animals there keep doing their thing, and spill_item_stack has to search a larger and larger area around an animal to find a free spot where it can drop its stuff.
I just locally commented out line 38 linked above, thus the event is never called. Makes no sense anyway to have all the eggs and poop, since - to me - it appears that the mechanics of this mod and Woodoria aren't finished; I wouldn't know what to to with these anyway.
Thought it might help someone running into similar behaviour.