If you had the positive bonuses setting enabled, this is a known issue and there is a warning about it in that setting's tooltip. It can happen when there is a huge number of power consumption possibilities due to too many combinations of beacons/modules/qualities.
As far as I know, that issue doesn't happen when only the negative bonuses setting is enabled. I just tried infinite quality tiers alongside this mod and the game runs fine. But it may be a hardware-dependent issue and related to system memory so if you get different results, that'd be useful info.
