Hope this is not a thing that's ment to be...
I ususally destroy biters in a grid with a combo of poison capsules (that I lob in), gun turrets at wall, and rockets for biter spawners...
Last one I did - I'm pretty sure I destroyed all spawners before opening the grid (buying it), but when it opened up there where 5 spawners there with full helth, and they where indestructible!!! Had to go into editor mode and uncheck the Indestructible checkbox to be able to kill them.
BTW - Fun overhaul - enjoying the mess so far... wish there where more info on features... like what the void grids with 4 blue chests are? supposed to do something with this? offer a material?
Those indestructible biters are a feature that was implemented to replicate the vanilla game mechanic of having to defend your base from biter attacks. I can maybe nerf the amount of biter bases or increase the minimum distance at which they can spawn. Currently, in 0.4.0, there's a 2.5% chance for any "safe" chunk to become an infested chunk, which has those unkillable spawners. I may also lower the chance. I prefer to not ruin anyone's game but give them at least some other challenge related to biters since they already have the freedom to confront biters whenever and wherever they want.
And yes, you offer materials other than coins in the blue chests around void chunks, and then attempt to unlock the void chunk. If the sum of items across all blue chests for a particular void chunk has a value of 10k coins or more, then the chunk is unlocked and turned into a dimensional chunk. This is where you can teleport to a void dimension and acquire infinite loot of some type, where the type of loot becomes better and better as you generate more void dimensions, eventually cycling back to its starting item, which is iron gear wheels. Version 1.0.0 will have some balance changes based on how easy it is to actually cheese this feature to get infinitely many science packs of all types.