Very much an edge case, and I was able to find a workaround with my save, but the internal buffer being so small makes for an interesting behaviour on systems that have no pipes otherwise.

This arose because I'm using this in conjunction with Factorissimo. The entire pipeline inside the building has a buffer of 12 fluid units (3 per pillar). With extreme crafting speeds (50 crafts per machine, ~300 fluid per second per machine; more than achievable in vanilla) some machines are bottlenecked.
In normal gameplay this'd be a non issue, because machines producing fluids have an output buffer themselves. Factorissimo basically acts as a pump as far as I know, so this particular bug might be reproducible without other mods too.

Workaround was to add "dummy" pipe segments that only act as small tanks. This fixes the issue completely.
Reference: https://imgur.com/m4e4rpV

Could you increase the internal buffer to be 100, the same as vanilla pipes?

Great mod otherwise, it's been a ton of fun designing prints with it so far!