This might not be a bug, but I can't come up with any other explanation.
In the save linked below, it seemed that after the most recent mod update (went from 0.17.51 to 0.17.59) our chest of nuclear fuel started getting eaten. That is, its contents vanished into the void.
I've removed and rebuilt the worker chest, toggled a few of the settings, and checked the debug output, but I can't figure out where the fuel is going. The production statistics show a huge discrepancy between fuel produced and fuel consumed, and I can't explain where the fuel is going. As soon as a piece of nuclear fuel is inserted in the worker chest, it disappears, but a number of entities across the map are not receiving fuel.
The fuel chest should be easy to find—there's a huge column of centrifuges producing nuclear fuel right next to it, near the uranium drop-off train stop.
Save: https://from.dgw.me/DDY_multiplayer.zip