What are your expectations for creep and pathing tiles? In my opinion that is a good double strike, that creep is a native "form of pathing tiles" -> can't co-exist with concrete/stone blocks.
Concerning rails it's a difficult question. Not everything is so simple about it in Factorio: https://forums.factorio.com/viewtopic.php?f=7&t=100847
In general (taking Creeper2 out of scope) if biters settle nests/worms and creep around them, then player effectively looses this territory unless turrets defend it. I do agree, that vanilla has some features around "outpost" concept, but if not turning on cheating options of rails infrastructure / big electric poles invincibility Rampant completely destroys outposts possibility, unless some armoured trains with equipment used... I asked about it a few years ago - no one replied.