Regenerative biters are designed to give the player an incentive to use flamethrowers. Otherwise, although they cannot kill, they drain defense. However, this becomes true from level 4 and above. Before that, they are weaker than average biters.
You need to change the settings of your game. I recommend trying the standard deathworld first. Even there the player will not always win
Also, according to my solo games, the death world 600 * 600 * 150 is already close to impossible - it requires dozens of save/load, including rollbacks of 2+ hours in order to fly away.
If you have Rampant Arsenal, the late game is easier, but still hard
Regarding the pipe attacks. Biters seek, find and destroy most unprotected objects. This is a feature of the mod. If you cannot protect something critical from them, you are guaranteed to lose.