The shotgun turret is a main staple for playing with Rampant and it can basically carry you to end-game using nothing but regular plain red ammo. It's my opinion that maybe this should be nerfed? The reason why it's so incredibly effective is because of its innate x2 damage modifier, which I think stacks multiplicatively with the turret damage technologies. The pellets deal so much damage that it can overpower even anti-physical mutations.
My suggestion would be to lower it to be in line with the MK2 Gun Turret, which only has a 20% innate damage bonus.
Edit: Not sure what happened there. Anyway, I realize since Rampant is very configurable, "end game" for me may not mean the same to others. But either way, I do believe that the Shotgun turret is too powerful as it is right now.