Currently 45 hours~ on my playthrough, the game is starting to slow down for the ammount of biters in the map and it seems it will get worse later on.
-Image: https://imgur.com/a/eSApS4b
-Save file: https://www.mediafire.com/file/ah39zgkm77gdcj8/t.zip/file --- https://forums.factorio.com/viewtopic.php?p=580294#p580294
Killing the biters with commands/nukes greatly increase the UPS, but this is only a momentary solution since they keep expanding.

I didn't experienced this problem without the new type of enemies before (2 years ago~), so I'll try starting from zero without them.

-Rampant 3.1.2
-Rampant on start
-Modlist:
AAI containers & Warehouses
AAI Industry
AAI Signal transmission
Afraid Of Darkness
Alien Biomes
Alien Biomes High Res Terrain
Armoured TraIN (Turret Wagons)
Armoured Biters
Auto Deconstruct
Bullet Trails
Combat Mechanics Overhaul
Disco Science Dragon Indusries - Nauvis Division
Endgame Combat
Enhanced Map Colors
Epic Artillery Sounds
Even Distribution
Factorio Library
Factorio Standard Library
Factory Planner
Honk
Informatron
Jetpack
LTN - Logistic Train Network
LTN Manager
Mod Base
Nanobots: Early bots
Power Armor MK3
Rampant
Rampant Arsenal
Rate Calculator
Robot Attrition
SE Space Trains
Shield Projector
Simulation Helper
Space Exploration ( and 5 graphic mods)
Space Exploration Early Logistic system-arans4-fork
Space Exploration Menu simulations
Space Exploration postprocess
Squeak Through
Text Plates
True Nukes
True Nukes Graphics
VehicleSnap
Warheads

Did you ever have other players join this map or on a server that you connect to as opposed to single player?

I was the host of it, playing with two friends (The lag persist even when I was alone)

This should be fixed in the latest. The issue had to do with players leaving the game and the mod thinking they still existed

We only ever played with 2 players and we would always play together. Would this bug have still affected us?