I've got a 23-hour factory with no loot chests built, but the mod installed. When I go to load the save, it takes about five seconds for the green bar to fill, and then a full 80 seconds until the game finishes loading and puts the world to play. I'd noticed that file load times have been progressively worsening as I've played, and after hacking my modlist down by over half (until it was pretty much just AngelBobs), it finally resolved itself after removing Loot Chest.
I'm not sure if the issue is that there's some table that doesn't get cleared as the game progresses, or perhaps it doesn't handle the removal of loot-type items (had Necromant and Alien Loot Economy installed earlier on the savefile), or if perhaps map chunks caused it to fail to clear something, but something is amiss.