We had used the mod in the multiplayer.
At the beginning everything was fine but with a bigger network it became unplayable (70 depots & 40-50 stations).
Deleting delivery and errors brought only very short relief. Hardware 4x3,4ghz 32gb ram of which 25-35% cpu load and 8% ram load.
We have a host pc that is not so good as yours. We have 600 stations, 80 trains, and hundreds of items, but we have no perfomance problems. Maybe a mod combination?