When re-aligning blueprints with rails in them, the blueprint gets irrevocably corrupted - for example, signals get moved into the rails.
Example blueprint before pressing an alignment hotkey:
0eNqd1u1ugyAUgOF7Ob9xEVARb2VZFm1JR9KCQbqsabz3YbuPbjXbOfxTIw9+vBrOMOyPZgzWRejOYDfeTdA9nmGyO9fvl2PxNBrowEZzAAauPyx7obd7mBlYtzVv0PH5iYFx0UZrruMvO6dndzwMJqQTfowsPnQGo5/SGO+WiZJTVOKhZnBKW7JNm2mGrQ1mcz1FzOwOFl/wFBO9e4nF5dpWaP0J8/9ZiWcVga3wbE1gazwrCWyDZzmBVWhWUl5ZS09MNZjEND0xhWB5SW8M5XJ6ZChX0CtDuZKeGcqt6J2h3O+vbfBDEfzgRx9iUf35IMS8Rt18Ycdhiv0ydh0q/4YUvdFGI+61pTeKcjW9UYwrSnqjKJfTG0W5gt4oypX0n2Gjfv8MmzW5yihNIq64zigN4zYZpWFclVEaxm0zSsO4OqM0hCvLjNL4fWlp/XhZYXY3C1IGryZM16lbXiktlNSKKy7n+R2SU3dp
After aligning the blueprint to any direction, it becomes corrupted, and cannot even be exported or saved anymore.