What other mods are you using?
If you don't mind sending me your save, that would help a lot. You could also send it on Discord if you'd prefer.
One other thing you could try if you're comfortable poking around inside the mod a bit is renaming control.lua
to something like control.unused
and starting up Factorio that way. This will break all the special lightning stuff but if the performance problems go away then we've found the problem.