It does if you are trying to send a signal as soon as construction has finished. Especially if that signal is intended to be recieved by part of the structure which may or may not have been build yet.
But if the combinator checks for the number of cells in the network when it updates, that solves all my issues.
There is also the work around of having the ghost combinator with a signal in the blueprint. The set signal vanishes as soon as ghost scanner is updated for the first time.