Randomizes recipes (amount of ingredients and products, crafting time) as well as many other things that can be toggled individually like belt speed, crafting speeds, energy consumption, weapon damage...
Currently doing a run and discovered T3 buildings have a reduced internal substation range causing some lights to be disconnected.
Looking through things it looks like "factory-power-pole" is the specific thing that needs matching blacklisting, its 63 supply area must have been reduced.