Thy this save: https://ufile.io/li1l8tnx
Please note that with all the varying mods I've played with, this has almost always been an issue.
I still cannot reproduce this locally, but you also sent me a save where purple science was already researched ... O_o
Anyway: after un-researching it, I still could not reproduce the issue using your save and your mods and settings synced, see: https://cloud.somenet.org/s/AGFM2Fn2QCr2Bsw
Please note that I do not particularly care about what issues your machine has, nor am I willing to go thru around 400mb worth of mods you play with to find the mods that may be incompatible and cause issues on your machine.
Unless you can produce a savegame file and a step by step guide on how to reliably reproduce this issue with a recent version of factorio and a minimal set of up to date mods (if this is some mod incompatibility thing), Im not investigating this further.
Also, get yourself some file hoster that is not trying to install malware (Im not downloading anything form ufile again).