I looked at the code and I know why I did not add support for deletion of chunks. It would require pretty complex tracking of chunks inside region and partial resource generation potentially.
Basic problem comes from the fact that deleting single chunks from region creates kind of holes and RSO would need to track them and try to regenerate resources inside them somehow. This could get pretty complex and I'm not planning to make such big changes to RSO currently.
So for now I'm affraid that RSO can be considered not compatible with "Regenerate Terrain" mod.