Biologically accurate evolution of bugs, they can evolve to build new nests, gather armies, smarter behavior, grow into higher tiers.
Mods introducing new content into the game.
New ways to deal with enemies, be it attack or defense.
Changes to enemies or entirely new enemies to deal with.
IE: Zombies, biters but older, The reploids if they werent from stargate and came from factorio
Only vanilla bugs are changed.