Hi Eagle,
I've got ~1600 hours and I've played this mod to completion on Vanilla, Krastorio2, and AngelBobs. The 3 factory pictures in the gallery are my bases from those playthroughs.
For difficulty, I found it moderately challenging to build a high throughput factory with the space constraints. Traditional busses use a lot of space, so I used novel layouts before I got to bots.
If you'd like it harder there's a mod setting to change how much landfill you get on each research, so you could set that to 0.75 or 0.5 for a tougher run.