To name a few big ones: can only remote-view (not enter as a god), technology would be locked to yours (no all-tech), sandboxes would contribute to production statistics. In other words, integrating some things necessarily means removing differences, so if you feel like it's different while you're in a sandbox, then it's likely that it wouldn't be much different anymore.
It wasn't possible before the remote-view. Now it is, it's just so different that it's hard not to consider it a completely separate mod.