I'm running a large mod pack so i'm not sure which mod is the cause of this error. Is there any testing I can do to assist in tracking it down?

Assembler Pipe Passthrough v2022.2.1

Error ModManager.cpp:1577: Error while loading entity prototype "seafloor-pump" (assembling-machine): Invalid pipe connections specification for offset {0.0000000000, -1.0000000000}. The offset must be outside of the entity bounding-box
Modifications: Offshore P.U.M.P.S. and ground water › Assembler Pipe Passthrough › Attach Notes › Natural Evolution Enemies (Redux) › AAI Industry

Providing a save game or modlist will be super helpful.

Not sure how to cleanly get a mod list so here is a copy of the latest save. It generates the noted error when enabling APP. https://www.dropbox.com/s/o6tey6qeo3czyz9/Bob%20Angels%20AAI%20stream%203.zip?dl=0

Thanks for the bug report; this has caused to be quite problematic, and ended up as a game bug report.
https://forums.factorio.com/viewtopic.php?f=7&t=101482

This is resolved in 2022.02.05 - please be aware this WILL BREAK your current fluid setups