My guess is a bad mod interaction as well - the only "big" mods I can think would interfere would be rampant, alien biomes, or space exploration (a new mod for me). So this has been one map/game, version locked on 0.17.66 via steam. No mods were changed/added/removed/updated during the game. That's the tricky part to me - nothing that I'm aware of has changed - and as a programmer change is something I'd try to be aware of!
Initially I would think it's not alien biomes, as it seems that biomes, in general, have had some spawns and some factory disappearances in each biome. I could see it being biomes if certain biomes had spawns and others did not, but it seems a fairly even distribution in those areas.
This is my mod list, I'm generally keeping it to "vanilla + qol" with the recent acquisition of space expansion/aai. I don't think there's much super crazy here, or overhaul like with the exception of space expansion and its required mods, which I've never used before.
30.984 Checksum of aai-industry: 1239965026
30.984 Checksum of aai-signal-transmission: 3335335418
30.984 Checksum of aai-signals: 2261738169
30.984 Checksum of aai-vehicles-chaingunner: 1784905760
30.984 Checksum of aai-vehicles-flame-tank: 1204028101
30.984 Checksum of aai-vehicles-laser-tank: 2959302605
30.984 Checksum of aai-vehicles-warden: 3121478813
30.984 Checksum of aai-zones: 764660141
30.984 Checksum of Advanced_Radar: 3518670224
30.984 Checksum of alien-biomes-hr-terrain: 2010945986
30.984 Checksum of Armor_pockets: 2238090784
30.984 Checksum of auto-research: 2958201390
30.984 Checksum of AutoDeconstruct: 2582707891
30.984 Checksum of bullet-trails: 3671570151
30.984 Checksum of cheaper_landfill: 2049989089
30.984 Checksum of DeathNotice: 335930257
30.984 Checksum of DiscoScience: 976323401
30.984 Checksum of DoubleFurnace: 1204716225
30.984 Checksum of ElectricTrain: 139130243
30.984 Checksum of FasterStart: 3040441678
30.984 Checksum of Fill4Me: 3404646308
30.984 Checksum of grappling-gun: 3754798104
30.984 Checksum of LSlib: 0
30.984 Checksum of Nuclear_Artillery: 613056033
30.984 Checksum of OpteraLib: 2463839464
30.984 Checksum of PlannerCore: 0
30.984 Checksum of Power Armor MK3: 4144768451
30.984 Checksum of qol_research: 3650033342
30.984 Checksum of replicating-belts: 2738724941
30.984 Checksum of robot_attrition: 4231589252
30.984 Checksum of space-exploration-graphics: 0
30.984 Checksum of SpaceMod: 3787441445
30.984 Checksum of specialized-oil-processing: 2049402329
30.984 Checksum of Squeak Through: 3677677690
30.984 Checksum of stdlib: 68667574
30.984 Checksum of themightygugi_alwaysday: 2560996361
30.984 Checksum of Turret_Range_Buff: 286452583
30.984 Checksum of walls-block-spitters: 2719996897
30.984 Checksum of Warehousing: 1077001093
30.984 Checksum of WaterWell: 4254977431
30.984 Checksum of aai-programmable-structures: 4071669958
30.984 Checksum of alien-biomes: 2878017637
30.984 Checksum of Orbital Ion Cannon: 2353690525
30.984 Checksum of OutpostPlanner: 1664633010
30.984 Checksum of Reinforced-Walls: 1586317742
30.984 Checksum of StorageTank2: 3685718469
30.984 Checksum of aai-programmable-vehicles: 3246729437
30.984 Checksum of Rampant: 4160344977
30.984 Checksum of space-exploration: 3810241182
30.984 Checksum of miniloader: 329218582
30.984 Checksum of space-exploration-postprocess: 2210159577
30.984 Checksum of WhistleStopFactories: 3860047069