Would it be possible to place the large factories in alignment with railroad tracks horizontally and vertically? That would simplify the blueprinting a lot.
They already are railroad aligned. The problem is that because they are 17x17, when you rotate a blueprint, the blueprint will no longer line up.
If I had to do it over, I'd make the entities 2n x 2n to allow better rotating of blueprints with rails in them, but that is a hard change to make at this stage.