The mod uses Factorio (API) to make screenshots, so there not much that can be done here without reducing the resolution.
Only thing is that by default the mod takes quite a bunch of screenshots (the timelapse is pretty slow). By increasing the speed gain, the timelapse will be faster (more time between each frame/screenshot), so there are less slow downs. But on each screenshot the slowdown will be there...
On long runs like pyanodon mods, it makes sense to only have 1 screenshot per 5 to 10 minutes, to prevent having a daylong timelapse in the end... So the slowdowns are really once in a while (5 to 10 minutes actually)
Note that removing other (unused) mods could free up your 'left over resources', giving more resources to the mod and having less severe slow downs. But this only works if you are not using those other mods (albeit them being loaded).
Buying a better PC of course also helps... :'(
All in all: not much you can do without compromising the quality I am afraid