It might be a good idea to add a few tiers of train research that boost hp of trains. Wagons and locomotives both. I've noticed as the game scales up the biters end up able to damage even nuclear trains badly enough to kill one car even when they pass at full speed. This causes the entire train to stop, causing a blockage, stopping more trains, which then get attacked by biters, etc...
Alternatively perhaps some sort of equipment that increases hp like armor? That would be interesting and have effects on lots of different things, trading space for hp maximum. I'm aware that quality does boost hp as well, of course, but having more options to protect trains as they go would be helpful.
Another interesting option would be a high-capacity low-regen shield which might specifically be suited for such situations, that has a lot of the traits of armor without needing some special system.