just got this mod with the new update but atm only vanilla SE or/and K2 are available for me
i am also useing 248k so i am missing a part for my run (SE+K2+248k)

I can't seem to be able to load the game with SE+K2+248k in Factorio 1.1.60, so I can't reproduce this.
Error while running setup for entity prototype "assembling-machine-3" (assembling-machine): next_upgrade target (fi_crafter_entity) must have the same collision mask.

But I would expect you to see 4 presets: SE, K2, SE+K2, and 248k.
There is no K2+248k or SE+248k or SE+K2+248k preset because I'm not familiar with the 248k mod so I wouldn't know what to add. But if you do make one, feel free to send me the exported string and I'll add it as a preset.

my presets are vanilla /vanilla extended and the mix of se and/or k2
no other mods and no 248k at all and yes i use .59 bcs the patch broke some mods

The 248k preset was added in Milestones 1.3.0 so if you're still on 1.2.2 then yeah, you wouldn't see it.

But you can always create your own set of items in the settings. Here's a copy of the 248k preset that you can paste in the "import" window to get you started:

[
    {type="item",       name="automation-science-pack", quantity=1},
    {type="item",       name="logistic-science-pack",   quantity=1},
    {type="item",       name="military-science-pack",   quantity=1},
    {type="item",       name="chemical-science-pack",   quantity=1},
    {type="item",       name="utility-science-pack",    quantity=1},
    {type="item",       name="production-science-pack", quantity=1},
    {type="item",       name="space-science-pack",      quantity=1},
    {type="item",       name="automation-science-pack", quantity=1000, next="x10"},
    {type="item",       name="logistic-science-pack",   quantity=1000, next="x10"},
    {type="item",       name="military-science-pack",   quantity=1000, next="x10"},
    {type="item",       name="chemical-science-pack",   quantity=1000, next="x10"},
    {type="item",       name="production-science-pack", quantity=1000, next="x10"},
    {type="item",       name="utility-science-pack",    quantity=1000, next="x10"},
    {type="item",       name="space-science-pack",      quantity=10000, next="x10"},

    {type="technology", name="el_stage_tech",           quantity=1},
    {type="technology", name="el_energy_tech",          quantity=1},
    {type="technology", name="fi_stage_tech",           quantity=1},
    {type="technology", name="fi_energy_tech",          quantity=1},
    {type="technology", name="fu_stage_tech",           quantity=1},
    {type="technology", name="fu_energy_tech",          quantity=1},
    {type="technology", name="gr_stage_tech",           quantity=1},

    {type="item",       name="el_materials_ALK",        quantity=1},
    {type="item",       name="el_energy_crystal_item",  quantity=1},
    {type="item",       name="fi_materials_glass",      quantity=1},
    {type="item",       name="fi_materials_gold",       quantity=1},
    {type="item",       name="fi_materials_neodym",     quantity=1},
    {type="item",       name="fi_materials_titan",      quantity=1},
    {type="item",       name="fi_materials_GFK",        quantity=1},
    {type="item",       name="fi_materials_NFK",        quantity=1},
    {type="item",       name="fi_energy_crystal_item",  quantity=1},
    {type="item",       name="fi_solid_reactor_item",   quantity=1},
    {type="item",       name="fu_materials_KFK",        quantity=1},
    {type="item",       name="fu_materials_TIM",        quantity=1},
    {type="item",       name="fu_materials_fusion_card",quantity=1},
    {type="item",       name="fu_materials_plasma_card",quantity=1},
    {type="item",       name="fu_materials_laser_card", quantity=1},
    {type="item",       name="fu_materials_magnet_card",quantity=1},
    {type="item",       name="fu_tech_sign_item",       quantity=1},
    {type="item",       name="fu_stelar_reactor_item",  quantity=1},
    {type="item",       name="fu_tokamak_reactor_item", quantity=1},
    {type="item",       name="fu_star_engine_core_item",quantity=1},
    {type="item",       name="fu_space_probe_science_item", quantity=1},
    {type="item",       name="gr_materials_circuit",    quantity=1},
    {type="item",       name="gr_materials_magnet",     quantity=1},
    {type="item",       name="gr_black_hole_item",      quantity=1},
    {type="item",       name="gr_white_hole_item",      quantity=1},

    {type="item",       name="gr_materials_red_item",   quantity=1},
    {type="item",       name="gr_materials_green_item", quantity=1},
    {type="item",       name="gr_materials_blue_item",  quantity=1},
    {type="item",       name="gr_materials_purple_item",quantity=1},
    {type="item",       name="gr_materials_yellow_item",quantity=1},
    {type="item",       name="gr_materials_grey_item",  quantity=1},
    {type="item",       name="gr_materials_white_item", quantity=1},

    {type="item",       name="locomotive",              quantity=1},
    {type="item",       name="el_diesel_train_item",    quantity=1},
    {type="item",       name="gr_magnet_train_pre_item",    quantity=1},
    {type="item",       name="gr_magnet_train_item",        quantity=1},
    {type="item",       name="construction-robot",      quantity=1},
    {type="item",       name="logistic-robot",          quantity=1},
    {type="item",       name="fu_robo_logistic_item",       quantity=1},
    {type="item",       name="fu_robo_construction_item",   quantity=1},

    {type="kill",       name="medium-biter",            quantity=1},
    {type="kill",       name="big-biter",               quantity=1},
    {type="kill",       name="behemoth-biter",          quantity=1},
    {type="kill",       name="behemoth-biter",          quantity=1000, next="x10"},
    {type="kill",       name="character",               quantity=1, next="x5"}
]

i was useing the most upto date version from ur mod at the time of my post on 1.1.59

but thanks for the string :)

Milestones 1.3.0 only works with Factorio 1.1.60 so you'll have to wait for things to get more stable to use the latest Milestones version.
Good luck! Let me know if you create an SE+K2+248k set, I am interested in adding it as a preset.