Saving a spidertron trash profile (click the green checkmark) crashes to menu if done in editor mode (aka no player character exists):
https://imgur.com/a/xFB5oKi
This can be reproduced with only base, Auto Trash, Editor Extensions, and Factorio Library mods installed. It can be worked around by toggling the map editor in EE to create a character. After this has been done once, saving and switching profiles seems to work even in editor mode.
Ideally, clicking the checkmark in editor mode would warn to create a player first or create one itself (i.e., by automatically toggling off editor mode briefly).

Fixed in the coming update.
When in editor mode it just saves the preset, without trying to recreate the characters gui. All presets created in editor mode will appear on the character once it's created.

Thanks!