Yeah. Take Infinite Quality Tiers as an example. Great little mod with 250 fucking qualities, but most of the icons are randomly colored. lol
Looking at that in a large base, you wouldn't be able to tell what quality something is. It could be anything.
In fact, I just did the math. For 5 pips and 3 colors (red, green, blue), there are about 3^5 possible combinations for the icons
I was just playing in Krita and thought of an approach:
Color the center of each pip of the x8 icon, in sequence, one color (red, green, or blue). It starts with one pip being colored green, the top-left one, then both top-left and top-right both green, and so on, incrementally coloring all the pips, leaving the center for last. Then, clear the colors back to the original x8, and color each pip the next color (red), with the same process as for green. The order of the colors can be in Factorio-style (GRB).
PS. Maybe instead of starting with green, the first color can be white, then GRB, then black.