Issue: When resarching The Real Enemies, the game freezes entirely. I can only close the game by ending the game via the Steam window. I do have turrets pre-placed amungst T.R.E.s with full ammo, if that is an issue.

Factorio version 1.1.76. (Steam current)

Additional Mods installed:
AAI Containers & Warehouses
AAI Signal Transmission
AAI Signals
Alien Biomes
Alien Bioes High-Res Terrain
Automatic Train Painter
Base Mod
Big Data String Library
Biter Factions
Blood & Gore Updated
Bottleneck Lite
Boxing 2
Cardinal
Clean Floor
Closest First for 1.1
Colur Blind Friendly Science packs
Custom Map Colors
Deadlock's Crating Machine
Desire Paths
Disco Science
Early Transport Drones
Factorio Library
Factorio Standard Library
Factorissimo2
Fluid Wagon Color Mask
Gear Girl Character
Gernade Yeet
Handcraft Timer
Honk
Humanoids 2 - Turns monsters into people again.
Jetpack
Labdanses Updated
Land Mine Thrower
Long Range Turrets
Mining Drones
Power Grid Comb
Prioritize Eneies PATCH
Production Scrap 2
Resource Map Label Marker
RP Item Anarchy
Scardey Bot
Shield Projector
Simulation Helper
Spidertron Logistics System
StartAlt
The real enemies
Toxic Forist
Train Trails
Transport Drones
Transport Drones on Asphalt
Ultimate Resarch Queue
Vehicle Trails
Water removes more pollution
WoodDoesBurn

I have gone into an earlier save, and removed the pre-placed turrents. Upon resarching T.R.E., the game freezes yet again.

Hey, sorry for replying late, didn't get any notification so didn't notice your message. Thanks for your report, I will look into it. Is it possible that you have shitton of enemies in your map?