Hello good Sir!
Xyrc's K2SO Enhancements setting "(Paracelsin) Endgame techs require galvanization tech card (Recommended)" crashes the game. I'm not sure if that setting is on by default, but Factorio shows me that it is.

To be exact, that setting adds galvanization pack to "kr-singularity-lab" research, and because Science Spread by default also does that - the game crashes. I can't test if other technologies after that one are affected, but chance that is the only one is slim.

The possible fix may be to check if said Xyrc's K2SO Enhancements is on and either disable "kr-singularity-lab" tech spread or exclude galvanization pack from it.

I'll check exactly what that mod does, and fix accordingly. I may be able to just set a hidden dependency.

Approach xyrc first, any fix here is very likely to become a cyclical dependency between the two mods, and that mod may also just want to override what I'm doing here anyways.

I see that it does changes to workshop science, and that mod also uses this library.

Opened the thread myself.

The fix is there, we'll see when it would get merged.
https://github.com/xyrc1/xy-k2so-enhancements/pull/19