well the biggest issue is all your circuits will need redone which will seriously limit your ability to automate their production as youll have to hand craft a bunch.
next issue is rare earth and phosphate ore needs to spawn so depending on how much map you've already revealed you'll have to travel a bit to find it.
other than that im not aware of to many issues that should stop you from doing so. just run this bit of code in the console after adding it to refresh the tech unlocks for anything you've already researched
/c for _,player in pairs(game.players) do
player.force.reset_recipes()
player.force.reset_technologies()
player.force.reset_technology_effects()
end