I just started a new 2.1 run and it seems to be working great except for science randomization.
From green onward (and even a few red sciences) the researches unlock what they do in vanilla.

(Btw, the mod seems to work with even distribution now)

Yes I've been patching up some of the mod incompatibility things here and there. According to the changelog this version was supposed to be compatible with any planet start even! But I forgot a couple steps...

Is that just on the default seed? What settings?

Thank you so much for your hard work!
There is always something hiding when you make a commit :P

I'm using the default seed
Bias: Best (thought I deserved it after fighting in another run)
Chaos: Ultimate
Logistics: More
Production: More
Military: Default
Miscellaneous: More
Technology prereqs: yes
Recipe ingredients: yes
Science recipes only: no
Recipe unlocks: yes
Duplicate unlocks: yes
Items: yes
Percent of items randomized: 100%
Item randomization attempts: 10
Unified randomization attempts: 10
All unified options: yes (delinearization: some)
The rest is off with the safeguarded algorithm

I'll list all my mods in case of known issues (obvious ones also included, just 'cuz):
Base mod
Elevated rails
Quality
Recycler
Space age
Artisenal redskins: Bob's assists
Auto deconstruct
Disco science
Even distribution
Exfret's randomizer
Factorio library
Helmod (I'll be removing this)
Milestone saves (I'll be removing this)
Milestones
Miner planner
Rate calculator
Tree healing

Are you able to send an empty save zip with these settings to my discord (link on information page)? That would greatly speed things up.

EDIT: If you're wondering why, it would allow me to just automatically sync everything instead of manually getting the settings etc. right :)

Sure! Dealing with dinner rn, so there might be a delay.

Done! Same username as here.

Identified the issue (sorry about the delay). Factorio 2.1 adds recipe unlocks for recycling recipes (before, they were unlocked from the start, just hidden and not possible to craft until you got the recycler anyways). This was sort of a curveball, which might have been fine but unified and non-unified randomizations currently work poorly with each other (I probably need to add warnings about this or something).

Identified a second issue that is more complex; working on it now.

Thanks for the info! I love gaining a bit more knowledge and understanding. And of course thanks for the hard work.

I'm having the same issue with these settings:
Bias: Best
Chaos: Ultimate
Logistics: More
Production: More
Military: More
Miscellaneous: More
Technology prereqs: off
Recipe ingredients: on
Science recipes only: off
Recipe unlocks: off
Duplicate unlocks: off
Items: on
Percent of items randomized: 100
Item randomization attempts: 10
Unified randomization attempts: 10
All unified options: on
Unified technology delinearization: Some
The rest is off with the safeguarded algorithm

Mods:
Base mod
Elevated rails
Quality
Recycler
Space age
Artisinal Reskins: Bob's Assets
Blueprint Shotgun
Bullet Trails
Disco Science
Even Distribution
exfret's Randomizer
Factorio Library
Milestones
Rate Calculator
Squeak Through 2

(edit: actually its not the same thing, the issue Im having is that everything that you normally unlock (without the randomizer) after green science doesnt have their crafting recipes randomized, except the items that were already randomized being replaced with their randomized versions)

(edit 2: Turning recipe unlocks on and unified recipe unlocks off seems to fix the issue)

Unified randomizations currently aren't working well with standard ones; I will have to disable the ability to have them simultaneously.