Dear Exfret,
i ran into a small issue on seed 1337 with the following settings:
Everything Default
Randomize technologies, recipies, unlocks and items
Percent 95
Algorithm Random-er

The problem is, that Depleted Uranium Fuel Cell got replaced with Jellynut Seeds, but Uranium Fuel Cells still turn into Depleted Uranium Fuel Cell in a reactor. Therefore, Jellynut Seeds become unobtainable, as they have no crafting recipe.
This is not an actual softlock on the seed, because existing Jellystem can be harvested and they are not required for any science pack, but it could be very annoying on other seeds.

My suggested solution is to adjust the spent result of Uranium Fuel Cells, when the corresponding item gets randomized.

Yes, apologies for this is a known issue that I haven't pushed an update for yet. Literally just three or so lines of code I commented out for some reason that shouldn't have been commented out. I didn't want to push an update just for fixing that one thing yet, especially since I'd want to fix it so that important things don't get turned into spent fuel results in general so that it would be a proper fix. Thanks for the report!